Our clinic has used IgM serologic testing to diagnose acute infection with DENV. Does documentation of a positive IgM for acute DENV infection in a child with symptoms of dengue make a child eligible for vaccination?

No. IgM tests for acute DENV infection are not sufficiently accurate to be acceptable evidence for the purposes of vaccination. These tests may be falsely positive as a result of other flavivirus infections that may cause similar symptoms (such as Zika).

Acceptable evidence of acute infection with DENV is either a positive dengue RT-PCR test result, or a positive dengue NS1 antigen test result.

Visit CDC’s website on laboratory testing requirements for vaccination with Dengvaxia for additional information: www.cdc.gov/dengue/vaccine/hcp/testing.html.