IZ Express

Issue 1875: May 27, 2026

Top Stories
 
Immunize.org Website and Clinical Resources 
 
Featured Resources
 
Notable Publications
 
Global News
 
Upcoming Events

Top Stories

Immunize.org updates "How to Administer Intranasal and Oral Vaccinations" to remove lyophilized Rotarix (GSK) presentation

Immunize.org recently updated its resource for healthcare professionals: How to Administer Intranasal and Oral Vaccinations to remove references to the lyophilized Rotarix (GSK) that required reconstitution before administration. All lots of this presentation have expired. All available Rotarix is in a fully liquid presentation that does not require reconstitution. The package insert continues to reference both formulations. 



Related Links


Immunize.org updates "Standing Orders for Administering Rotavirus Vaccine to Infants" to remove lyophilized Rotarix (GSK) presentation

Immunize.org updated its Standing Orders for Administering Rotavirus Vaccine to Infants. The changes include the removal of lyophilized Rotarix to remove references to the lyophilized Rotarix (GSK) that required reconstitution before administration. All lots of this presentation have expired. All available Rotarix is in a fully liquid presentation that does not require reconstitution. The package insert continues to reference both formulations. 



Related Links


Measles 2026: 1,952 confirmed measles cases in 39 states so far this year

As of May 21, CDC reported 59 new measles cases in the previous week, reaching 1,952 confirmed measles cases for 2026. All but 9 cases were infected while in the United States. So far, 39 jurisdictions have reported measles cases in 2026. Specific numbers from CDC and individual state websites may differ slightly, as the frequency and timing of federal and state updates vary.

The measles outbreak that started along the Utah-Arizona border is the largest active outbreak at this time.

Below is a map from CDC showing measles cases among U.S. residents as of May 21.



Vaccine coverage rates may vary considerably from community to community within a state. Pockets of unvaccinated people can accumulate in states with high vaccination coverage, creating conditions favorable for an outbreak if measles is introduced. Vaccination remains extremely effective. Immunize.org offers measles-related resources for the public on several of our affiliated websites:

Related Links
FDA updates selected vaccine labeling to include “protect from light” language; recommended storage practices unchanged

On May 14, 2026, FDA revised product labeling for several GSK vaccines to include "protect from light" language. This change reaffirms CDC's long-standing, routine vaccine storage recommendation to keep vaccines in original, closed packaging to protect from light until just before administration. FDA’s labeling revisions do not alter these routine storage practices.

Related Links


Looking for our online travel vaccine content? Watch our 3-minute Orientation Video Series: “Introducing Travel Vaccine Information” 

Learn how to navigate Immunize.org’s travel vaccine information for healthcare professionals and the public with our 3-minute Orientation Video Series: Introducing Travel Vaccine Information. In this video, Kelly Moore, MD, MPH, reviews sections of the Immunize.org website, tailored to healthcare professionals, to help you find important information on vaccination before traveling abroad. In addition, she introduces the travel vaccine resources for the public that were added to our affiliated website, www.VaccineInformation.org in 2025.

The entire Orientation Video Series is available on our YouTube channel.



Share these videos with anyone who wants to learn more about effective immunization practices with Immunize.org.


Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.


Immunize.org Website and Clinical Resources

Spotlight on the website: locate published vaccine recommendations from ACIP and healthcare professional organizations 

This week’s spotlight shines on recommendations from CDC and healthcare professional organizations. Under the Official Guidance tab, view the respective guidance in the “CDC” and “Healthcare Professional Organizations (HPOs)” submenus. The smartphone view appears below.



CDC: The “ACIP Vaccine Recommendations” web page provides “Comprehensive” or “Vaccine-Specific Recommendations” published in MMWR. Filter content by “Vaccine or Disease Name,” “Status” (current or archived), or “Date” (newest or oldest). Links go to content on CDC.gov or a PDF document.



Healthcare Professional Organization (HPOs): This section has similar filters. Additionally, you can filter results by “Organization” or “Patient Age.” The recommendations under Comprehensive Recommendations are for specific patient populations (e.g., pregnant patients or those who are immunocompromised) and include multiple vaccines. The recommendations from HPOs may be published in journal articles or on the organizations’ websites.

Related Link


Featured Resources

Vaccine champions will love Immunize.org's "Save Lives. Immunize." T-shirts

Immunize.org is pleased to offer T-shirts in three designs (unisex, women’s, and baseball). Each T-shirt features our logo on the front and, on the back, our tag line: “Save Lives. Immunize.” These T-shirts are fashioned in a super soft, premium tri-blend fabric that doesn’t shrink or wrinkle with washing. Designed with frontline vaccinators in mind, they pair perfectly with scrub pants for vaccination clinics and make a pro-vaccine statement whenever you or your team want to show your support for immunization. Perfect for the gym, clinic, or anywhere you like!

Three designs include:

   
     


Notable Publications

“Childhood Vaccine Hesitancy” published in New England Journal of Medicine

In its May 20 issue, New England Journal of Medicine published Childhood Vaccine Hesitancy. The summary appears below.

Vaccine hesitancy exists along a spectrum; most parents with hesitancy are motivated to protect their children but are often concerned about safety. Routine childhood vaccines recommended by the American Academy of Pediatrics have substantially reduced the incidence of disease and maintain a strong safety record. Clinicians are the most trusted source of vaccine information, and clear, confident recommendations are closely linked to higher uptake. Presumptive communication approaches are more effective than open-ended approaches, especially when paired with respectful dialogue. Empathy-driven, patient-centered strategies, including motivational interviewing, help address concerns, counter misinformation, and build trust while preserving relationships that may encourage future vaccination decisions.


“Clusters of Concern—Spatial Link Between Childhood Undervaccination and Measles Outbreaks in South Carolina” published in New England Journal of Medicine

In its May 20 issue, New England Journal of Medicine published Clusters of Concern—Spatial Link Between Childhood Undervaccination and Measles Outbreaks in South Carolina. Portions of the letter appear below.

These findings indicate that undervaccination in South Carolina is concentrated in geographic clusters. The spatial alignment between hot-spot tracts and measles-exposed schools suggests that geographic clustering of undervaccinated students may serve as a precursor to outbreak activity. The concentration of documented measles exposures in Spartanburg County may reflect the geographic overlap between clusters of undervaccination and a close-knit community that is concentrated in that area, whereas the geographic separation of other undervaccinated hot spots from the Spartanburg cluster may have prevented measles from spreading more broadly. . . . With measles outbreaks active in multiple states, proactive spatial surveillance of high-risk clusters may support earlier, more targeted public health interventions to reduce barriers to immunization, prevent further clustering, and enhance outbreak-control efficiency.


“Federal Vaccine Injury Compensation Programs: Overview and Current Issues” published online by KFF

KFF (formerly Kaiser Family Foundation) published a review titled Federal Vaccine Injury Compensation Programs: Overview and Current Issues. Portions of the introduction appear below:

For decades, the federal government has overseen two key vaccine injury compensation programs: the National Vaccine Injury Compensation Program (VICP) and the Countermeasures Injury Compensation Program (CICP). The VICP and CICP are designed to help maintain vaccine access while also recognizing that vaccine injuries can occur and those affected by such injuries should be compensated. . . .

To provide background and context on this topic, this brief summarizes the history and rationale for these programs and their key elements, analyzes publicly available information on claims and compensation under the programs, and discusses key policy issues they currently face. The programs, while both having been created as alternatives to civil courts, vary significantly in their structures, processed, vaccines covered, and compensation rates and amounts, among other factors.


“SARS-CoV-2 Vaccination Before and During Pregnancy and Prevention of Infant COVID-19 Infection” published in Pediatrics

In its May 1 issue, Pediatrics published SARS-CoV-2 Vaccination Before and During Pregnancy and Prevention of Infant COVID-19 Infection. Maternal vaccination at any time during pregnancy was most effective at preventing infant COVID-19-related hospitalizations in the first 6 months of life. Portions of the abstract and a link to the video abstract appear below.
 


We examined the effectiveness of maternal messenger RNA SARS-CoV-2 vaccination before and during pregnancy in preventing COVID-19 in infants aged 0-6 months born between July 1, 2021, and June 30, 2023, at Kaiser Permanente Northern California. . . .

Among 78 644 infants, 3648 (4.6%) had COVID-19 infection and 76 (0.1%) experienced COVID-19-related hospitalization before age 6 months. For the 4 prepregnancy vaccination intervals, estimates for VE (vaccine effectiveness) against COVID-19 infection ranged from -14.9% . . . for less than 3 months prepregnancy to 23.6% . . . for more than 12 months prepregnancy. VE anytime during pregnancy was 7.5%. . .against infant COVID-19 infection and 52.9% . . . against infant COVID-19-related hospitalization. Effectiveness of third-trimester vaccination was 19.2% . . . against infant COVID-19 infection and 64.6% . . . against infant COVID-19-related hospitalizations. . . .


Maternal vaccination during the third trimester was protective against infant COVID-19 infections. Maternal vaccination during pregnancy, particularly during the third trimester, was effective against infant COVID-19-related hospitalizations. Vaccination before pregnancy did not protect infants.


“Clinician Perceptions of the Impact of Switching HPV Vaccine Initiation to 9–10 Years” published in Pediatrics

In its May 1 issue, Pediatrics published Clinician Perceptions of the Impact of Switching HPV Vaccine Initiation to 910 Years. Portions of the abstract appear below.

Although HPV vaccine initiation as early as aged 9 years has been recommended, most clinicians initiate at ages 11 to 12 years. We assessed clinician-reported impact of early initiation on parental responses and vaccine discussions. . . .

As part of an ongoing cluster randomized pragmatic trial across 31 Colorado and California pediatric practices, we allocated practices to switch HPV vaccine initiation to ages 9 to 10 years or to enhanced usual care (initiation at ages 11 to 12 years). All clinicians received online training on improving HPV vaccination; intervention arm clinicians also received training on initiating at ages 9 to 10 years. We surveyed all clinicians in both arms at 1, 6, 12, 18, 24, 30, and 36 months (all >80% response rates), and queried clinicians in the ages 9 to 10 years arm about vaccination at ages 9 to 10 vs 11 to 12 years. . . .

Almost all intervention arm clinicians switched rapidly to the ages 9 to 10 years initiation; most control clinicians remained at ages 11 to 12 years. Parental concerns/questions, pushback, hesitancy, and adherence to recommendations did not differ significantly between study arms and were similar at ages 9 to 10 vs 11 to 12 years among intervention arm clinicians. Only about one-tenth of clinicians in both arms brought up sexual activity during HPV vaccine discussions; two-thirds in both arms indicated parents sometimes/often did. Intervention arm clinicians were more likely than controls to state discussions were shorter by a lot/little (55% vs 37%, P = .005) since study initiation. . . .

Initiating HPV vaccination at ages 9 to 10 years instead of ages 11 to 12 years had little impact on parental questions/concerns, pushback, hesitancy, or clinicians' ability to convince hesitant parents. Initiation at ages 9 to 10 years was perceived by clinicians to shorten HPV vaccine discussions.


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Global News

WHO releases World Health Statistics 2026: Monitoring Health for the SDGs, Sustainable Development Goals

On May 13, the World Health Organization (WHO) published World Health Statistics 2026: Monitoring Health for the SDGs, Sustainable Development Goals. The 2026 edition presents global health and sustainable development goal indicators, assessing progress, highlighting key challenges, and examining major health trends and inequalities. Portions of the report appear below.

Routine immunization coverage for core childhood vaccines . . .  including vaccines against diphtheria-tetanus-pertussis, measles, pneumococcal disease caused by Streptococcus pneumoniae and human papillomavirus, has largely stalled and remains lower than the Immunization Agenda 2030 global target of 90% . . .

Coverage with the third dose of diphtheria-tetanus-pertussis-containing vaccines (DTPCV3) has plateaued at around 85%. Meanwhile, the second dose of measles-containing vaccines (MCV2) lagged behind at 76% in 2024, far below the levels needed to prevent outbreaks. As immunity gaps persist, several regions are reporting rising measles transmission.

Coverage with the third dose of pneumococcal conjugate vaccines (PCV3) has steadily increased to 67% in 2024, reflecting its introduction in more countries. Human papillomavirus (HPV) vaccination has shown the fastest growth – primarily driven by recent introduction in some countries – with global coverage increasing from 12% in 2021 to 28% in 2024. However, this rapid progress starts from a very low baseline (Fig. 1.8).




Download the entire report World Health Statistics 2026: Monitoring Health for the SDGs, Sustainable Development Goals (PDF).


Upcoming Events

Virtual: Summit Adult Vaccine Recommendations Review (SAVRR) Council hosts public meeting on June 9 at 2:00 p.m. (ET) to describe the Council, its purpose, and procedures that guide its work

Vaccinators and vaccine recipients face unprecedented challenges as vaccination recommendations of federal, state, and healthcare professional organizations proliferate and diverge. The Summit Adult Vaccination Recommendations Review (SAVRR) Council is an independently funded committee of the National Adult and Influenza Immunization Summit (NAIIS), known as “the Summit,” dedicated to supporting implementation of evidence-based vaccination recommendations in this new environment.

The SAVRR Council will host its first public webinar online 2:00–3:00 p.m. (ET) on June 9.

The SAVRR Council is composed of a broad range of voting member organizations and observers whose representatives have been screened by their organizations for conflicts of interest. All participating organizations and their representatives are listed at the SAVRR web page. Vaccine manufacturers and trade organizations do not participate in SAVRR meetings and do not provide any financial support for the Council. The objectives of the SAVRR Council are twofold:

  1. Serve as a forum to provide practical, diverse stakeholder feedback to organizations making vaccination recommendations
  2. Support clinical implementation of evidence-based vaccination recommendations by identifying challenges to implementation and recommending strategies to increase affordable access and vaccine use
Working meetings of the SAVRR Council occur monthly, with quarterly public meetings planned. The initial 1-hour public webinar will describe its purpose and the procedures that guide its work. In addition, it will review the SAVRR Council’s preliminary recommendations for effective implementation of fall respiratory vaccination recommendations. The meeting will conclude with discussion of plans for future open meetings and opportunities for ongoing engagement. Immunize.org administers and serves as the fiscal agent for the NAIIS and the SAVRR Council.

Register for the meeting.

Related Links
Virtual: Register for Immunize.org Website Office Hours. Join a 30-minute discussion about our Vaccine Confidence & Addressing Concerns web content on June 10 at 4:00 p.m. (ET) or June 11 at 12:00 p.m. (ET). Recorded sessions archived.

To learn simple tips and tricks for using our websites efficiently, please register for our next set of Website Office Hours on Wednesday, June 10, at 4:00 p.m. (ET) or Thursday, June 11, at 12:00 p.m. (ET). The same content will be covered in both sessions.

We will open each 30-minute session with a short, live demonstration on navigating our Vaccine Confidence & Addressing Concerns website section. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize.org Website Office Hours (content is the same for both):

The archive of previous Website Office Hours content is posted at Immunize.org’s "Webinars & Videos" page.

Mark your calendar for future Immunize.org Website Office Hours.


For more upcoming events, visit our Calendar of Events.

About IZ Express

IZ Express is supported in part by Grant No. NH23IP922654 from CDC’s National Center for Immunization and Respiratory Diseases. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.

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ISSN 2771-8085

Editorial Information

  • Editor-in-Chief
    Kelly L. Moore, MD, MPH
  • Managing Editor
    John D. Grabenstein, RPh, PhD
  • Associate Editor
    Sharon G. Humiston, MD, MPH
  • Writer/Publication Coordinator
    Taryn Chapman, MS
    Courtnay Londo, MA
  • Style and Copy Editor
    Marian Deegan, JD
  • Web Edition Managers
    Arkady Shakhnovich
    Jermaine Royes
  • Technical Reviewer
    Kayla Ohlde

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