IZ Express

Issue 1869: April 15, 2026

Top Stories
 
Immunize.org Website and Clinical Resources 
   
Featured Resources
 
Notable Publications
 
Upcoming Events

Top Stories

Blue Cross and Blue Shield companies issue statement on continued coverage for ACIP-recommended vaccines through 2027

On April 3, Blue Cross and Blue Shield (BCBS) companies released a statement regarding their insurance coverage of ACIP-recommended vaccines. Their commitment to investing in ongoing coverage of recommended vaccines with no out-of-pocket expense to patients makes it clear that they value and support vaccination. Importantly, healthcare professionals are reassured they can continue to purchase, offer, and administer recommended vaccines with the confidence that BCBS will continue to pay for vaccination services. The statement is reprinted below.

Blue Cross and Blue Shield (BCBS) companies consistently hear that members want continued access to vaccines, and that health care providers value clear guidance on coverage and payment.

To provide certainty, continuity and peace of mind, BCBS companies will continue the commitment we made in 2025, to cover all ACIP-recommended (Advisory Committee on Immunization Practices) immunizations with no cost sharing through 2027, while operating within federal and state laws and meeting program and customer requirements.

As always, decisions regarding vaccinations are made between patients and their health care providers, and BCBS companies will continue to apply rigorous, evidence-based processes when evaluating coverage policies.


As influenza and COVID-19 wane, late RSV activity continues in parts of United States; most jurisdictions advise continuing RSV preventive antibody products for infants

Influenza activity continues to wane nationally, with most of the remaining circulating influenza virus identified as Type B. COVID-19 levels are very low across the country. RSV is the remaining preventable winter respiratory virus with significant activity nationally.

RSV preventive antibody products, nirsevimab (Beyfortus, Sanofi) and clesrovimab (Enflonsia, Merck), are routinely recommended from October through March in most of the contiguous United States. This season, the National Respiratory and Enteric Viruses Surveillance System continues to show RSV activity persisting later in the year than usual, with ongoing elevated RSV risk to infants in some regions where this is not typical. Individual public health jurisdictions are responsible for directing recommendations to extend RSV preventive antibody product administration beyond March, particularly for newborns, based upon local RSV epidemiology. 

Only one dose of Beyfortus or Enflonsia is recommended for most infants. Infants with certain risk factors for severe RSV disease are the only ones recommended to receive a preventive antibody product as they enter their second RSV season. This means that most infants who receive RSV preventive antibody now, during this unusually late season, will not be due for RSV immunization at the beginning of the next RSV season in October.

The Association of Immunization Managers (AIM) collects information on this season’s changes in recommendations for use of RSV preventive antibody products from the 66 federally funded immunization program jurisdictions (including states, certain cities or counties, and territories). On April 2, AIM posted a map showing current RSV preventive antibody guidance, based on available information. As of April 1, 48 jurisdictions extended their RSV preventive antibody administration season through April 30. Rhode Island and Philadelphia extended through April 15 and will reassess the situation. Two jurisdictions were undecided and four did not recommend extending use of RSV antibody products, although Virginia and Missouri will consider requests by VFC program participants to extend administration dates for their patients on a case-by-case basis. Ten jurisdictions already maintain year-round RSV preventive antibody administration policies due to the year-round circulation of the virus in their areas.

Visit the color-coded map and supporting documentation for each jurisdiction's status on AIM's website for details on your jurisdiction. 



Nationwide RSV activity and vaccination rates reported by CDC are highlighted below.

  • Respiratory Illnesses Data Channel:
    • RSV activity started later than expected in most regions of the United States, though illness is not more severe compared with recent seasons. This unusual timing means higher levels of RSV activity may continue through April in many regions. Emergency department visits and hospitalizations for RSV are highest among infants and children less than age 4 years.
  • RSVVaxView:
    • Among the reporting eight state and city IIS jurisdictions, preventive antibody coverage among infants younger than age 8 months (born since April 1, 2025) ranged from 34.2% to 52.5%.  Among five U.S. territorial and affiliated island jurisdictions, coverage ranged from 0% to 31.1%.
    • As of February 2026, among females with an infant born since April 2025, 65.1% of infants were reported to be protected against RSV through either maternal RSV vaccination with Abrysvo (Pfizer) only (9.4%) or through a preventive antibody product (55.7%).
    • As of February 22, 2026, 43.2% of adults age 75 years and older and 32.8% of adults age 50–74 years with a high-risk condition for RSV reported having ever received an RSV vaccine.
Related Links
Measles 2026: 1,714 confirmed cases in first 4 months; Utah outbreak with 583 cases this year and climbing

As of April 9, CDC reported 1,714 confirmed measles cases for 2026, 75% of the number of cases reported in all of 2025. So far, 32 states have reported measles cases in 2026. Notable updates include:

  • The outbreak in Utah is currently the fastest growing outbreak in the United States. Utah Department of Health and Human Services confirmed 583 cases since the beginning of 2026, with 121 cases reported in the past 3 weeks.
  • The South Carolina Department of Public Health confirmed 997 cases of measles since October 2025: no new cases have been reported since March 17. A measles outbreak may be declared over once there are no new outbreak-associated cases identified for two incubation periods (42 days).
  • Arizona’s outbreak is on the border with Utah and connected to the larger Utah outbreak. Arizona Department of Health and Human Services confirmed 292 cases in 2026, with 15 new cases in March.
CDC only requires reporting of laboratory-confirmed measles cases. Cases without laboratory testing for confirmation are not included in these numbers. Actual numbers of cases are, therefore, higher than confirmed case counts.

The chart below shows the age distribution of U.S. measles cases since January 1, 2025, from the Johns Hopkins International Vaccine Access Center measles tracker. At least 56% of cases occurred in children younger than age 18 years. All of these children have access to two doses of MMR vaccine with no out-of-pocket expense, either through private insurance or the federal VFC program.



Immunize.org offers measles-related resources for the public on several of our affiliated websites:
Related Links
“Why Is It Important to Vaccinate Babies Against Rotavirus?” See this 1-minute video, part of the Ask the Experts Video Series on YouTube.

Our newest video in the Ask the Experts Video Series is titled Why Is It Important to Vaccinate Babies Against Rotavirus? This video briefly describes the importance of vaccination against rotavirus, the most common vaccine-preventable cause of severe gastroenteritis in infants and young children in the United States and worldwide.

The 1-minute video is available on our YouTube channel along with our full collection of quick video answers to popular Ask the Experts questions.

Like, follow, and share Immunize.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.


Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.


Immunize.org Website and Clinical Resources

Spotlight on the website: Immunize.org website adapts to your mobile device!

The Immunize.org website adapts seamlessly to the smaller screens of tablets and smartphones. The site’s menu automatically adjusts to different screen sizes and device types. It features easy-access links for finger scrolling. 
 
When you open the Immunize.org site on a mobile device, start your search using the “hamburger” icon (three horizontal lines) or search feature at the top right of the screen. From that menu, you will see content categories. Immunize.org provides an impressive array of content, no matter how you view us. 



 

The Orientation Video Series, narrated by Immunize.org’s Kelly L. Moore, MD, MPH, specifically formatted for mobile devices, showcases resources offered on Immunize.org in short videos: 


Featured Resources

From the Immunize.org shop! Laminated VIS QR code tables deliver CDC VISs directly to your patients’ smartphone (Spanish translation version also available).

The Immunize.org team is pleased to introduce durable, laminated tables of QR codes linking to VISs for vaccines given to children and adults. VISs explain both risks and benefits of vaccination. Federal law requires you to document provision of CDC’s current VIS before administering any vaccine covered by the Vaccine Injury Compensation Program. CDC recommends VISs accompany other vaccines, too. An easy, paperless way to comply with the law is for patients to scan a QR code and access the VIS from a smartphone or tablet. 

CDC produces official VISs only in English. CDC does not produce or certify available translations, so the official CDC VIS should accompany any translation.



These new tables belong in any room where vaccinations are given. Key features include: 

  • Durable quality: The tough laminate coating can be wiped down.
  • Never out-of-date: Any time a VIS or translation is updated, the QR code will direct to the new VIS.  
  • Use as a booklet or poster: The laminated table arrives folded like a newspaper. It is suitable for desk use as an 8.5" x 11" booklet or wall mounted as an 11" x 17" poster.
  • One version for official CDC VISs and one for Spanish translations: The table of official CDC VISs in English is sold individually. The table of Spanish translations is sold as a bundle with the table of official VISs so it is easy to make both available.
  • Spanish version usable by non-Spanish speakers: The Spanish QR code table has side-by-side text in English to support its use by non-Spanish speakers.
  • Easy access to all available translations: Both versions include a QR code link to the Immunize.org index of all VIS translations available in dozens of languages.
  • Bonus content: The reverse side of the QR code poster includes links to Immunize.org's “Addressing Vaccination Anxiety” resources and additional VIS content. 

Pricing (includes all shipping and handling costs)

Laminated CDC VIS QR Code Table (English)
1 copy: $14.00
2 copies: $9.00 each
3–4 copies: $6.50 each
5–9 copies: $5.00 each
10–19 copies: $4.00 each
20–59 copies: $3.00 each
60+ copies: $2.50 each

Bundle: Laminated CDC (English) + Spanish Translation VIS QR Code Tables
(each bundle includes 1 CDC VIS table and 1 table of Spanish translations)

1 bundle: $20.00
2 bundles: $16.00 each
3–4 bundles: $12.00 each
5–9 bundles: $8.50 each
10–19 bundles: $7.00 each
20–59 bundles: $6.00 each
60+ bundles: $5.00 each



Visit the Shop Immunize.org: Laminated VIS QR Code Tables web page to view images and order today! For additional information, call 651-647-9009 or email admininfo@immunize.org


Notable Publications

“Pediatric Vaccine Effectiveness Against Influenza Hospitalization and Outpatient Visits: 2021–2024” published in Pediatrics

In its April 6 issue, Pediatrics published Pediatric Vaccine Effectiveness Against Influenza Hospitalization and Outpatient Visits: 2021–2024. A portion of the abstract appears below.

We used data from 7 US pediatric medical centers within the New Vaccine Surveillance Network. We included children aged 6 months to 17 years who were hospitalized or received outpatient care for acute respiratory illness (ARI). We estimated VE [vaccine effectiveness] against influenza-associated hospitalizations and outpatient visits with subgroup analyses for each season . . . 

VE overall ranged from 34% to 60% across seasons, with the lowest VE estimates during 2021 to 2022. Effectiveness was 53% against influenza A/H1N1, 43% against A/H3N2, and 69% against B, with further variation by clade. . . .

From 2021 to 2024, pediatric influenza VE ranged from 34% to 60%, and overall was effective at preventing influenza-associated hospitalizations and outpatient visits. Effectiveness was higher against influenza B and lower during the 2021 to 2022 season. Vaccine uptake was low among children, with only half or fewer receiving the influenza vaccine each season. Influenza vaccination is the best way to reduce the risk of influenza for children. Improved pediatric influenza vaccination uptake would prevent additional influenza-associated hospitalizations and outpatient visits.


A video abstract is available.


“The Impact of a Pneumococcal Vaccination on Disease Activity in Children and Adolescents with Inflammatory Bowel Disease: A 2-Year Prospective Study” published in Expert Review of Vaccines

In its March 30 issue, Expert Review of Vaccines published The Impact of a Pneumococcal Vaccination on Disease Activity in Children and Adolescents with Inflammatory Bowel Disease: A 2-Year Prospective Study. The study was designed to evaluate whether PCV13 administration was associated with flare ups in pediatric inflammatory bowel disease (IBD) patients. The study concluded that a single dose of PCV13 does not increase inflammatory bowel disease activity in pediatric IBD patients during the 24 months following vaccination. A portion of the abstract appears below.

Infectious diseases are known triggers for inflammatory bowel disease (IBD) exacerbations. Although vaccines can prevent many such infections, hesitancy persists among pediatric IBD patients and their caregivers due to concerns about vaccine-induced disease flare-ups. The aim of the study was to evaluate the impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on disease activity in children and adolescents with IBD over a 24-month period post-vaccination. . . .

This prospective, multicenter cohort study included IBD patients aged 4–18 years. Participants were assigned to a vaccinated group (single PCV13 dose) or an unvaccinated control group. Disease activity was monitored using PUCAI/PCDAI
[Pediatric Ulcerative Colitis Activity Index/ Pediatric Crohn’s Disease Activity Index] scores, and exacerbation rates were recorded at 6, 12, 18, and 24 months. . . .

A total of 279 patients (52.3% male; median age, 167 months) were enrolled, of whom 93 (33.3%) received PCV13. The control group showed higher, but not statistically significant, disease activity at any time point (p = 0.06 . . .) and exacerbation rates (p = 0.47 . . .). . . .

A single dose of PCV13 does not increase disease activity in pediatric IBD patients during the 24 months following vaccination.


Upcoming Events

Virtual: NFID hosts webinar titled “Addressing the Resurgence of Measles” on April 21 at 12:30 p.m. (ET); CME credit offered

NFID will host a webinar titled Addressing the Resurgence of Measles at 12:30 p.m. (ET) on April 21. The panel includes NFID Medical Director Robert H. Hopkins, MD; NFID Director Matthew M. Zahn, MD; and Anna-Kathryn Burch, MD, associate professor of pediatric clinical medicine at the University of South Carolina School of Medicine. 

Speakers will discuss current vaccine recommendations for measles and provide effective strategies to help increase vaccine uptake in the United States. 

CME credit is available. There is no fee to participate in this activity, but preregistration is required.

Register for the webinar.

NFID hosts monthly webinars to increase awareness of the importance of infectious disease prevention and treatment. CME, CNE, and CPE credits are available for select recordings. View archived NFID webinars.


Virtual: North Dakota State University Center for Immunization Research and Education hosts webinar titled “Who Decides the Vaccine Schedule, How Did We Get Here, and Where Are We Going?” on April 28 at 1:00 p.m. (ET); CE credit offered

The North Dakota State University (NDSU) Center for Immunization Research and Education will host a webinar titled Who Decides the Vaccine Schedule, How Did We Get Here, and Where Are We Going? at 1:00 p.m. on April 28. During this webinar, chair of the American Academy of Pediatrics Committee on Infectious Diseases, Sean O’Leary, MD, MPH, University of Colorado School of Medicine, will discuss how vaccines are licensed, how recommendations developed in the United States, and how to confidently address common questions about routine immunizations.

This activity is approved for free continuing medical education credit and continuing pharmacy education credit.

Register for the webinar.


Virtual: NFID hosts webinar titled “Closing the Gap: Strategies for Increasing HPV Vaccination Rates” on April 29 at 2:00 p.m. (ET); CME credit offered

NFID will host a webinar titled Closing the Gap: Strategies for Increasing HPV Vaccination Rates at 2:00 p.m. (ET) on April 29. The panel includes NFID Medical Director Robert H. Hopkins, MD; Michelle D. Fiscus, MD, Association of Immunization Managers (AIM), and Robin S. O’Meara, MD, Michigan State University College of Human Medicine.

Speakers will discuss current HPV vaccine recommendations, vaccination accessibility and coverage, and communication strategies to increase vaccine confidence. 

CME credit is available. There is no fee to participate in this activity, but preregistration is required.

Register for the webinar.

NFID hosts monthly webinars to increase awareness of the importance of infectious disease prevention and treatment. CME, CNE, and CPE credits are available for select recordings. View archived NFID webinars.


Virtual: Register for Immunize.org Website Office Hours. Join a 30-minute discussion about our News & Updates web content on May 13 at 4:00 p.m. (ET) or May 14 at 12:00 p.m. (ET). Recorded sessions archived.

To learn simple tips and tricks for using our websites efficiently, please register for our next set of Website Office Hours on Wednesday, May 13, at 4:00 p.m. (ET) or Thursday, May 14, at 12:00 p.m. (ET). The same content will be covered in both sessions.

We will open each 30-minute session with a short, live demonstration on navigating our News & Updates website section. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize.org Website Office Hours (content is the same for both):

The archive of previous Website Office Hours content is posted at Immunize.org’s "Webinars & Videos" page.

Mark your calendar for future Immunize.org Website Office Hours.


For more upcoming events, visit our Calendar of Events.

About IZ Express

IZ Express is supported in part by Grant No. NH23IP922654 from CDC’s National Center for Immunization and Respiratory Diseases. Its contents are solely the responsibility of Immunize.org and do not necessarily represent the official views of CDC.

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ISSN 2771-8085

Editorial Information

  • Editor-in-Chief
    Kelly L. Moore, MD, MPH
  • Managing Editor
    John D. Grabenstein, RPh, PhD
  • Associate Editor
    Sharon G. Humiston, MD, MPH
  • Writer/Publication Coordinator
    Taryn Chapman, MS
    Courtnay Londo, MA
  • Style and Copy Editor
    Marian Deegan, JD
  • Web Edition Managers
    Arkady Shakhnovich
    Jermaine Royes
  • Technical Reviewer
    Kayla Ohlde

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