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Results (1355)
COVID-19
Administering Vaccines
How does CDC define being “up to date” on COVID-19 vaccination? [Video]
All three RSV vaccines are currently licensed and recommended as a one-time dose for any person. Data are not available at this time to make recommendations for revaccination. At this time, a pregnant person who receives Abrysvo (Pfizer) during one pregnancy is not recommended to receive Abrysvo during a subsequent pregnancy: in subsequent pregnancies, the baby should receive nirsevimab (Beyfortus, Sanofi) after delivery for RSV protection. ACIP will make decisions concerning RSV revaccination as more data become available over time.
Last reviewed:
August 25, 2024
Meningococcal ACWY
Vaccine Recommendations
Should college students be vaccinated against meningococcal disease with MenACWY vaccine? [Video]
If a healthcare worker does not have a history of varicella vaccination or disease but has had a clinically diagnosed case of shingles, does she or he still need varicella vaccination?
No. A healthcare provider’s diagnosis or verification of a history of shingles is acceptable evidence of immunity to varicella. According to ACIP, acceptable evidence of varicella immunity in healthcare personnel includes (1) documentation of 2 doses of varicella vaccine given at least 28 days apart, (2) history of varicella or herpes zoster based on clinician diagnosis, (3) laboratory evidence of immunity, or (4) laboratory confirmation of disease.
Last reviewed:
May 16, 2023
Hepatitis A
Disease Issues
Are people with chronic liver disease at higher risk of acquiring hepatitis A virus (HAV) infection?
No. People with chronic liver disease are not at increased risk for acquiring HAV infection. However, they are at an increased risk for life-threatening, fulminant (severe and sudden) hepatitis if they become infected with hepatitis A. People considered to have chronic liver disease include those with hepatitis B or C infection, cirrhosis, fatty liver disease, alcoholic liver disease, and autoimmune hepatitis.
Last reviewed:
June 25, 2023
Scheduling Vaccines
Two live virus vaccines can be given on the same day. How do you define “day”?
The “same day” generally means at the same visit. This interval has not been precisely defined and probably will never be since it would be extremely difficult to study in order to develop an evidence-based recommendation. Immunization programs (and their computer systems) likely define this differently. It seems reasonable that if two vaccines were given on the same date then they would both be valid.
Last reviewed:
June 6, 2023
Vaccine Recommendations
Which vaccines are recommended for healthcare personnel (HCP)?
ACIP recommends that people working in healthcare settings be vaccinated against influenza, hepatitis B, measles, mumps, rubella, varicella, and pertussis. For measles, mumps, rubella, and varicella, serologic evidence of immunity is an acceptable substitute for documentation of vaccination. In addition, microbiologists working in a laboratory should receive meningococcal conjugate and meningococcal serogroup B vaccines. In rare cases, some laboratory personnel should also receive polio and typhoid vaccines. For more information, see www.cdc.gov/mmwr/pdf/rr/rr6007.pdf.
Last reviewed:
August 22, 2020
Vaccine Safety
Is there any harm in giving an extra dose of MMR to a child of age seven years whose record is lost and the mother is not sure about the last dose of MMR?
No. In general, although it is not ideal, receiving extra doses of vaccine poses no medical problem. Receiving excessive doses of tetanus toxoid (e.g., DTaP, DT, Tdap, or Td) can increase the risk of a local adverse reaction, however. For details, see Extra Doses of Vaccine Antigens in the ACIP’s “Best Practice Guidelines for Immunization” at www.cdc.gov/vaccines/hcp/acip-recs/general-recs/timing.html.
Vaccination providers frequently encounter people who do not have adequate documentation of vaccinations. Providers should only accept written, dated records as evidence of vaccination. With the exception of influenza vaccine and pneumococcal polysaccharide vaccine, self-reported doses of vaccine without written documentation should not be accepted. An attempt to locate missing records should be made whenever possible by contacting previous healthcare providers, reviewing state or local immunization information systems, and searching for a personally held record.
If records cannot be located or will definitely not be available anywhere because of the patient’s circumstances, children without adequate documentation should be considered susceptible and should receive age-appropriate vaccination. Serologic testing for immunity is an alternative to vaccination for certain antigens (e.g., measles, rubella, hepatitis A, diphtheria, and tetanus).
Last reviewed:
August 31, 2022
Rabies
My patient did not return for his postexposure rabies vaccine dose on day 7. How should I manage his series now?
Every attempt should be made to adhere to the recommended vaccination schedules. Once vaccination is initiated, delays of a few days for individual doses are unimportant, but the effect of longer lapses of weeks or more is unknown. Most interruptions in the vaccine schedule do not require reinitiation of the entire series. For most minor deviations from the schedule, vaccination can be resumed as though the patient were on schedule. For example, if a patient misses the dose scheduled for day 7 and presents for vaccination on day 10, the day 7 dose should be administered that day and the schedule resumed, maintaining the same interval between doses. In this scenario, the remaining doses would be administered on days 17 and 31. When substantial deviations from the schedule occur, immune status should be assessed by performing serologic testing 7–14 days after administration of the final dose in the series. Postexposure prophylaxis with rabies vaccine is described in detail at www.cdc.gov/mmwr/pdf/rr/rr5902.pdf.
Last reviewed:
May 14, 2023
Polio
If an immigrant infant has a record of 1 or 2 doses of oral polio vaccine (OPV) in their country of origin how many more doses of IPV should be given?
Polio vaccine given outside the United States is valid if written documentation indicates that all doses were given after 6 weeks of age and the vaccine received was IPV or trivalent OPV (tOPV). Only trivalent polio vaccine counts toward the U.S. schedule. No doses of OPV given since April 1, 2016, count toward the U.S. polio vaccination schedule because, on that date, all countries routinely using tOPV switched to bivalent OPV. Please see other detailed answers concerning details on assessment of OPV doses by the date of administration.
If both tOPV and IPV were or will be administered as part of a series, the total number of doses needed to complete the series is the same as that recommended for the U.S. IPV schedule. If the child is younger than 4 years of age a total of 4 doses of polio vaccine are recommended. If the child is currently 4 years of age or older, a total of 3 doses completes the series. A minimum interval of 4 weeks should separate doses in the series, with the final dose administered on or after the fourth birthday and at least 6 months after the previous dose. If only tOPV was administered, and all doses were given before 4 years of age, 1 dose of IPV should be given at 4 years of age or older, at least 6 months after the last tOPV dose.
Last reviewed:
July 23, 2023
Rotavirus
Vaccine Recommendations
Can preterm infants receive rotavirus vaccine?
ACIP supports vaccination of preterm infants according to the same schedule and precautions as full-term infants and under the following conditions: if the infant’s chronological age meets the age requirements for rotavirus vaccine (for example, age 6 weeks to 14 weeks 6 days for dose #1), the infant is clinically stable, and the vaccine is administered at the time of discharge from the hospital or after discharge from the hospital.
Last reviewed:
June 7, 2023
Dengue
Vaccine Recommendations
Is Dengvaxia recommended for travelers to dengue endemic areas?
No, it is not. It is only recommended for children and teens ages 9 through 16 who reside in dengue endemic areas.
Last reviewed:
February 16, 2022
Zoster (Shingles)
Vaccine Recommendations
My clinic cannot consistently keep Shingrix in stock due to high demand. How should we handle challenges ensuring patients receive a second dose?
Clinicians and patients should make every effort to ensure that two doses of Shingrix are administered within the recommended interval of 2 to 6 months. If more than 6 months have elapsed since the first dose of Shingrix, administer the second dose when possible. Do not restart the vaccine series.
Who should be tested for anti-HBs after vaccination?
Serologic testing for immunity is not necessary or recommended after routine vaccination of infants, children, or adults. Testing for anti-HBs after vaccination is recommended for the following groups whose subsequent clinical management depends on knowledge of their immune status:
Infants born to HBsAg-positive women and infants born to women whose HBsAg status remains unknown (for example, infants surrendered shortly after birth); postvaccination serologic testing should consist of testing for anti-HBs and HBsAg and should not occur before age 9 months
Healthcare professionals and public safety workers at risk for blood or body fluid exposure
Hemodialysis patients (and other persons who might require outpatient hemodialysis), people living with HIV, and other immunocompromised people (such as hematopoietic stem-cell transplant [HSCT] recipients or people receiving chemotherapy), to determine the need for revaccination and the type of follow-up testing, and
Sex partners of HBsAg-positive people, to determine if they have not achieved immunity and will need revaccination and to continue to use other methods of protection against HBV infection.
Testing of individuals other than infants should be performed 1–2 months after administration of the final dose of the vaccine series using a method that allows determination of a protective concentration of anti-HBs (10 mIU/mL or higher). Testing of infants should take place after administration of the final dose of the vaccine series when the infant is age 9 through 12 months. Testing should not be done earlier than 9 months to avoid inadvertent detection of HBIG administered at birth and to maximize the likelihood of detecting HBV infection, if present.
Last reviewed:
July 21, 2023
MMR (Measles, Mumps, and Rubella)
Vaccine Recommendations
If there is an outbreak in my area, can we vaccinate children younger than 12 months?
MMR can be given to children as young as 6 months of age who are at high risk of exposure such as during international travel or a community outbreak. However, doses given BEFORE 12 months of age cannot be counted toward the 2-dose series for MMR.
Last reviewed:
June 19, 2023
Combination Vaccines
DTaP-IPV-HepB (Pediarix, GSK)
We have been giving Pediarix (DTaP-HepB-IPV) to children who are overdue for DTaP #4, IPV #3, and HepB #3. Is this an acceptable practice?
No. Pediarix is intended to be used only for doses 1, 2, or 3 of the DTaP primary series; consequently, using Pediarix for DTaP #4 is off-label and not recommended. You should take measures to prevent this error in the future. The DTaP, IPV, and HepB doses given in this scenario do not need to be repeated as long as you met the recommended minimum intervals for each vaccine component (DTaP, IPV, HepB). If you did meet the minimum intervals, the doses should be counted as valid.
Last reviewed:
July 15, 2023
Contraindications & Precautions
Which vaccines are recommended to be given postpartum to mothers of newborns before hospital discharge?
The following vaccines are recommended for new mothers before they leave the hospital: (1) mothers without documentation of previous Tdap vaccination need a dose to protect themselves; (2) mothers who did not receive influenza vaccination during pregnancy need to be vaccinated if it is still influenza vaccination season (October through March); (3) mothers who tested susceptible to rubella on prenatal testing need MMR vaccine even if they have 1 or 2 documented doses of MMR in their medical record; (4) mothers who are not immune to chickenpox need 2 doses of varicella vaccine – the first dose before hospital discharge and the second dose 4 to 8 weeks after the first dose.
Last reviewed:
August 29, 2022
Diphtheria
Vaccine Recommendations
Pertussis
Vaccine Recommendations
Tetanus
Vaccine Recommendations
As a pediatrician, I am concerned about protecting my newborn patients from pertussis, especially given the recent outbreaks in my community where infants have died. How many doses of pediatric diphtheria-tetanus-acellular pertussis (DTaP) vaccine does an infant need before she or he is protected from pertussis?
Vaccine efficacy is 80%–85% following 3 doses of DTaP vaccine. Efficacy data following just 1 or 2 doses are lacking but are likely lower. The most effective way to prevent pertussis in early infancy is to vaccinate the mother between 27 and 36 weeks’ gestation. Antipertussis antibodies generated by the mother’s immune system are passed across the placenta to the fetus. One dose of Tdap should be administered during each pregnancy, preferably between 27 and 36 weeks’ gestation. Available data suggest that vaccinating closer to 27 weeks will maximize passive antibody transfer to the infant. A CDC evaluation found Tdap vaccination during the third trimester of pregnancy prevents 78% of pertussis cases in infants younger than 2 months of age and that maternal vaccination reduces the risk of infant hospitalization for pertussis by 90% (www.cdc.gov/pertussis/hcp/vaccine-recommendations/vaccinating-pregnant-patients.html).
Last reviewed:
March 31, 2022
Documenting Vaccination
If my state has an Immunization Information System (IIS, or registry) do I still need to give the patient a vaccine record card?
Yes. Patient-held cards are an extremely important part of a person’s medical history. The person may move to another state or need medical care at a facility within or outside the state without access to the IIS in which their records are documented, and the personal record may be the only vaccination record available.
Last reviewed:
June 6, 2023
Hib (Haemophilus influenzae type b)
Scheduling & Administration
If a healthy infant received one dose of Hib at 5 months, and another at 15 months, does he/she need any more doses?
No. If a healthy child receives a dose of Hib vaccine at 15 months of age or older, he or she does not need any further doses regardless of the number of doses received before 15 months of age.
Last reviewed:
July 31, 2022
Storage & Handling
Vaccine Storage Units
Is it okay to store medications and other biologic products in the same unit as vaccines?
CDC’s Vaccine Storage and Handling Toolkit states that if other medications and biological products must be stored in the same unit as vaccines, they must be clearly marked and stored in separate containers or bins from vaccines. Potentially contaminated items (e.g., blood, urine) should be properly contained and stored below vaccines due to risk of contamination from drips or leaks. The freezer of a household-grade unit may be used for non-vaccine, medical storage, so long as the use does not compromise the temperature range within the refrigerator compartment where vaccine is stored.
Last reviewed:
July 26, 2023
HPV (Human Papillomavirus)
Vaccine Recommendations
Are catch-up recommendations for the use of HPV vaccine different for males and females?
No. In June 2019, the Advisory Committee on Immunization Practices (ACIP) voted to recommend routine catch-up HPV vaccination of all previously unvaccinated or incompletely vaccinated males age 22 through 26, matching the recommendation for females. HPV vaccination recommendations now differ by age group only, not by biological sex. There is a routine recommendation for vaccination of all people 9 through 26 years of age and a shared clinical decision-making recommendation based on risk and preference for people 27 through 45 years of age.
Under section 564 of the Federal Food, Drug, and Cosmetic Act (FD&C Act), the FDA Commissioner may allow unapproved medical products or unapproved uses of approved medical products to be used in an emergency to diagnose, treat, or prevent serious or life-threatening diseases or conditions caused by chemical, biological, radiological or nuclear threat agents when there are no adequate, approved, and available alternatives. Vaccines that receive an EUA may later be fully licensed by the FDA.
Last reviewed:
August 31, 2024
Meningococcal B
Vaccine Recommendations
Should college students be vaccinated against meningococcal serogroup B disease?
Several small outbreaks of meningococcal serogroup B disease have occurred on college campuses since 2013. However, the disease incidence in college students remains very low (0.03 cases per 100,000 college students age 18 to 24 years in 2020). ACIP does not routinely recommend MenB vaccine for college students. However, the recommendation for shared clinical decision-making applies to all college students age 16 through 23 years who may choose to receive MenB vaccine to reduce their risk of meningococcal serogroup B disease. In addition, some colleges and universities require MenB vaccination for incoming students.
If a college student completes the MenB vaccine series at least 6 months to 1 year before being identified as at risk during an outbreak, a single booster dose of the same brand can boost levels of protective antibodies within 1-2 weeks. The ability to be protected quickly during an outbreak by a single booster dose may be an important consideration for college students, families, and administrators when deciding about getting the MenB vaccine primary series.
Last reviewed:
March 24, 2024
Meningococcal ACWY
Vaccine Recommendations
Several healthy adult college students from outside the U.S. (ages 24 years and older) presented to our clinic. They will be living in a residence hall. None have a record of having received MenACWY. Should the receive a dose of MenACWY now?
Yes. One dose of MenACWY vaccine is recommended for all first-year college students who are or will be living in a residence hall if they are previously unvaccinated, have not received a dose of MenACWY since turning 16, or if their most recent dose (given after turning 16) was not given within the past 5 years.
Last reviewed:
November 15, 2024
Administering Vaccines
General Issues
A 5-year-old is in the office for vaccines and is due for MMR, polio, varicella, and DTaP. Is there a specific order I should be giving these vaccines?
The Advisory Committee on Immunization Practices (ACIP) does not address this issue. There is no recommended order in which the vaccines should be given. A best practice strategy to decrease injection or procedural pain is to administer the vaccine that causes the most pain (stinging, for example) last. For more information on vaccine administration, please see the “Vaccine Administration” chapter of Epidemiology and Prevention of Vaccine-Preventable Diseases at www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-6-vaccine-administration.html.
Last reviewed:
December 28, 2022
RSV (Respiratory Syncytial Virus)
Vaccine Products
Can any of the three licensed RSV vaccines be used during pregnancy?
Only the RSVpreF vaccine, Abrysvo by Pfizer, is licensed and recommended for one-time use between 32 weeks and 36 weeks 6 days of gestation to prevent RSV-associated lower respiratory tract disease in infants younger than 6 months old. Do not use Arexvy (GSK) or mResvia (Moderna) during pregnancy. If a pregnant person received an RSV vaccine before the current pregnancy, do not use Abrysvo during this pregnancy. Instead, counsel them that a dose of nirsevimab (Beyfortus, Sanofi) will be needed to protect the infant from RSV after birth.
Last reviewed:
August 25, 2024
Pneumococcal
Vaccine Products
What are the recommendations for pneumococcal vaccination of children and adults?
The recommendations for pneumococcal vaccination of children and adults vary depending upon the specific vaccines available, and the recipient’s age, pneumococcal vaccination history, and medical or behavioral risk factors. CDC has summarized all of its recommendations at this site: www.cdc.gov/pneumococcal/hcp/vaccine-recommendations/index.html.
How many doses of pediatric diphtheria-tetanus-acellular pertussis, or DTaP, vaccine does an infant need before she or he is protected from pertussis? [Video]
Several healthy adult college students from outside the U.S. (ages 24 years and older) presented to our clinic. They will be living in a residence hall. None have a record of having received vaccination against meningococcal ACWY disease. Should they receive a dose of MenACWY now? [Video]
I have a patient who is 52 years old and is immigrating to the U.S. She received a dose of recombinant zoster vaccine at age 50. The immigration requirements state she should receive 2 doses of varicella vaccine. Does she need additional varicella vaccine?
Recombinant zoster vaccine (RZV, Shingrix, GSK) does not count as the first of two doses of varicella vaccine. Shingrix is not licensed and has not been evaluated for the prevention of primary varicella infection. To meet the immigration requirements, you should give a dose of varicella vaccine now and a second dose at least 4 weeks later. The varicella vaccine doses will not be harmful and will allow your patient to meet the regulatory requirement.
Last reviewed:
May 16, 2023
Rabies
Can a pregnant person receive rabies vaccine if exposed to rabies?
Yes. A pregnant person should receive rabies vaccine if indicated. No fetal abnormalities have been reported with the rabies vaccine. A pregnant person can receive routine pre-exposure vaccination against rabies if the risk of exposure is high.
Last reviewed:
August 30, 2020
Hepatitis A
Disease Issues
Please discuss the tests commonly used to diagnose hepatitis A.
Hepatitis A cannot be differentiated from other types of viral hepatitis on the basis of clinical or epidemiological features alone. Appropriate blood tests must be used.
Anti-HAV: Total antibody to HAV. This diagnostic test detects total antibody of both IgG and IgM subclasses of HAV. If positive, it indicates either acute or resolved infection.
IgG anti-HAV: IgG antibody is a subclass of anti-HAV. It appears early in the course of infection, remains detectable for the person’s lifetime and provides lifelong protection against disease. Its presence indicates immunity through either HAV infection or HepA vaccination.
IgM anti-HAV: IgM antibody is a subclass of anti-HAV. Its presence indicates a recent infection with HAV (6 months or less). It is used to diagnose acute (recently acquired) hepatitis A. Because of the risk of false positive IgM anti-HAV results, people should only be tested for IgM anti-HAV if they are symptomatic and suspected of having acute hepatitis A illness.
HAV RNA tests also may be used to diagnose acute infection through the direct detection of viral RNA in serum or stool.
Total anti-HAV, which appears early in the course of infection, remains detectable for the person’s lifetime and indicates lifelong protection against the infection/disease. To confirm a diagnosis of acute HAV infection, serologic testing for IgM anti-HAV is required. In the majority of persons, serum IgM anti-HAV becomes detectable 5 to 10 days before onset of symptoms and lasts about 6 months. However, there have been reports of persons who test positive for IgM anti-HAV for up to a year or more following infection. An educational program on the interpretation of hepatitis A serology is available on the CDC website at www.cdc.gov/hepatitis/hcp/training/.
Last reviewed:
June 25, 2023
Scheduling Vaccines
For the purpose of vaccine spacing, what constitutes a month: 28 days (4 weeks), 30 days, or 31 days?
For intervals of 3 months or less, you should use 28 days (4 weeks) as a “month.” For intervals of 4 months or longer, you should consider a month a “calendar month”: the interval from one calendar date to the next a month later. This is a convention that was introduced on the childhood schedule in 2002 and discussed in the paper “Evaluation of Invalid Vaccine Doses” (Stokley S, Maurice E, Smith PJ, et al. American Journal of Preventive Medicine, 2004; 26[1]: 34–40).
Last reviewed:
June 6, 2023
Vaccine Recommendations
Where can I get the most up-to-date information on vaccination recommendations for people who travel outside the U.S.?
You can get this information from CDC’s Travel Health website at wwwnc.cdc.gov/travel/. CDC also publishes Health Information for International Travel (a.k.a. the “Yellow Book”) as a reference for those who advise international travelers of health risks. The Yellow Book is written primarily for healthcare providers, although others might find it useful. The contents of the book are available on the CDC Travel Health website. The book can also be ordered in print form. Information on how to order it is on the Yellow Book website at wwwnc.cdc.gov/travel/page/yellowbook-home.
Last reviewed:
August 22, 2020
Vaccine Safety
What is the Vaccine Adverse Event Reporting System (VAERS)?
As the name implies, VAERS is a nationwide system for monitoring adverse events following vaccination. VAERS is operated jointly by the FDA and the CDC since 1990.
Last reviewed:
August 31, 2022
Polio
Our adult patient has been accepted to a physician assistant program that requires polio vaccine for all students. She has 2 documented doses of oral polio vaccine (OPV) as a child, then recently had a dose of inactivated polio vaccine (IPV). How many more doses of IPV does she need to complete the series and on what schedule?
People who receive a mixed series of OPV and IPV should receive a total of either 3 or 4 doses depending on the age at the time of the last dose. In this case the recent dose of IPV can be counted as the third and final dose in the series. The minimum interval between the next-to-last and last doses in the polio vaccination series is 6 months and the last dose should be at age 4 years or older.
Last reviewed:
July 23, 2023
Storage & Handling
Vaccine Storage Units
Can you please guide me in finding storage containers and bins for vaccines?
CDC recommends the use of bins, baskets, or some other type of uncovered containers that allow for organization and air circulation for vaccines and diluents within the storage unit. Storage in boxes or bins can help maintain temperature longer, especially if power is lost. Perforated bins may allow for better air circulation around the vaccine, thus helping to maintain correct temperature.
CDC does not have a specific recommendation for brands of containers or bins for storage of vaccine. We recommend that you contact your state immunization program, as they may have suggestions for purchasing this equipment. If you are a Vaccines for Children (VFC) program provider, you should contact your immunization program to ensure that you are in compliance with VFC policy.
Last reviewed:
July 26, 2023
Rotavirus
Vaccine Recommendations
We have a 20-week-old infant who was born prematurely. The infant has never received rotavirus vaccine and is technically past the maximum age for first dose. Should we give rotavirus vaccine to this infant?
ACIP recommends vaccination of preterm infants according to the same schedule and precautions as full-term infants. In preterm infants (as in full-term infants), the maximum chronological age for the first dose is 14 weeks 6 days. Vaccination should not be initiated for infants aged 15 weeks 0 days or older because of insufficient data on safety of dose 1 of rotavirus vaccine in older infants. For more information, see page 19 of ACIP’s recommendations on rotavirus vaccination, available at www.cdc.gov/mmwr/PDF/rr/rr5802.pdf.
Last reviewed:
June 7, 2023
Administering Vaccines
General Issues
Do we need to wait for the vaccine to reach room temperature before we administer it to a patient?
With the exception of two vaccines used to prevent smallpox or mpox (previously known as monkeypox), there is no recommendation to wait until a vaccine reaches room temperature before administration. The vaccine should be administered as soon as it is prepared.
The live smallpox (vaccinia) vaccine, ACAM2000 (Emergent Product Development Gaithersburg, Inc.) and the non-replicating, live smallpox and mpox vaccine, Jynneos (Bavarian Nordic) should be brought to room temperature before use, according to the package inserts for these two products.
Last reviewed:
December 28, 2022
MMR (Measles, Mumps, and Rubella)
Vaccine Recommendations
How does being born before 1957 confer immunity to measles?
People born before 1957 lived through several years of epidemic measles before the first measles vaccine was licensed in 1963. As a result, these people are very likely to have had measles disease. Surveys suggest that 95% to 98% of those born before 1957 are immune to measles. Persons born before 1957 can be presumed to be immune. However, if serologic testing indicates that the person is not immune, at least 1 dose of MMR should be administered.
Last reviewed:
June 19, 2023
Zoster (Shingles)
Vaccine Recommendations
Should Shingrix be given to people who have already received Zostavax? If so, what interval should separate them?
Yes. ACIP recommends that people who previously received Zostavax receive 2 doses of Shingrix. The first dose of Shingrix may be given a minimum of 8 weeks after Zostavax.
Last reviewed:
March 9, 2022
Combination Vaccines
DTaP-IPV/Hib (Pentacel, Sanofi)
Please describe the combination vaccine DTaP-IPV/Hib (Pentacel) and how it should be used.
FDA licensed Pentacel in 2008 as a 4-dose series in infants and children at ages 2, 4, 6, and 15–18 months. It should not be used for any dose in the primary series for children age 5 years or older or as the booster dose for children ages 4 through 6 years. The DTaP-IPV component is supplied as a sterile liquid, which is used to reconstitute lyophilized (freeze-dried) ActHIB vaccine. The two components of the vaccine should be stored together in the carton to reduce the chance of giving one component of the vaccine without the other. The DTaP-IPV component should never be administered alone.
Last reviewed:
July 15, 2023
Contraindications & Precautions
Is it acceptable practice to administer MMR, Tdap, and influenza vaccines to a postpartum mom who received RhoGam after delivery?
I have a patient who is 24 years old and lives in Puerto Rico. He had confirmed dengue in 2014 and is requesting dengue vaccination. Should we vaccinate him?
No. Dengvaxia is FDA-licensed only for children and teens ages 9 through 16 years.
Last reviewed:
February 16, 2022
Diphtheria
Vaccine Recommendations
Pertussis
Vaccine Recommendations
Tetanus
Vaccine Recommendations
My 11-year-old patient received a dose of Tdap when he was 7 years old. He also received a dose of Td 6 months later in order to finish a primary series of tetanus-toxoid. Can I give him a dose of Tdap now?
Yes. The January 2020 ACIP updated statement on the use of Tdap (available at www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6903a5-H.pdf) states that a child who receives a dose of Tdap from age 7–9 years as part of the catch-up series (as in this case), should receive another dose of Tdap at age 11 or 12 years.
Last reviewed:
March 31, 2022
Documenting Vaccination
Please explain the federal requirements for all healthcare providers that administer vaccines under the National Childhood Vaccine Injury Act.
The National Childhood Vaccine Injury Act (NCVIA), enacted in 1986, set forth 3 basic requirements for all vaccination providers, which are:
Providers must give the patient (or parent/legal representative of a minor) a copy of the relevant federal “Vaccine Information Statement” (VIS) for the vaccine they are about to receive.
Providers must record certain information about the vaccine(s) administered in the patient’s medical record or a permanent office log.
Providers must document any adverse event following the vaccination that the patient experiences and that becomes known to the provider, whether or not it is felt to be caused by the vaccine, and submit the report to the Vaccine Adverse Event Reporting System (VAERS) at https://vaers.hhs.gov.
Last reviewed:
June 6, 2023
Hib (Haemophilus influenzae type b)
Scheduling & Administration
Since the booster dose of Hib vaccine can be given at 12–15 months, is it still necessary to “boost” two months later if the first dose was given at 12–14 months?
If the child received a primary series (2 or 3 doses) of Hib vaccine in the first year of life, then the final (booster) dose of the series may be given as early as 12 months, provided at least 2 months have passed since the last dose. An unvaccinated 12–14-month-old child should receive one dose as a primary series, and a booster dose 2 months later. Unvaccinated healthy children 15–59 months of age need only a single dose of any licensed conjugate Hib vaccine. Some high-risk children 15–59 months of age are recommended for two doses of Hib vaccine based on previous history of incomplete vaccination.
Last reviewed:
July 31, 2022
HPV (Human Papillomavirus)
Vaccine Recommendations
What are the recommendations for use of HPV vaccine in people age 27 through 45 years?
Catch-up HPV vaccination is not recommended for adults older than 26 years of age. Instead, shared clinical decision-making regarding HPV vaccination is recommended for some adults aged 27 through 45 years who are not adequately vaccinated and want to be protected from ongoing risk of acquiring new HPV infection.
Ideally, HPV vaccine should be administered before potential exposure to HPV through sexual contact.
Last reviewed:
March 2, 2024
Hepatitis B
Tests & Interpretation
I have a patient who is positive for anti-HBc (hepatitis B core antibody) but negative for other hepatitis B serologic markers. Should he receive hepatitis B vaccine?
Some isolated positive anti-HBc results are false positives (it is the most common false positive HBV marker). If that can be established, the individual can and likely should be vaccinated, assuming there is an indication or desire to be protected. If the positive anti-HBc is believed to be a true positive, the individual would not require vaccination since they have already (presumably) had HBV infection. Isolated positive anti-HBc could indicate low-level chronic infection. In an infant isolated anti-HBc could indicate passive transfer of antibody from a mother who is HBsAg positive, which is why anti-HBc testing of infants is not recommended.
The MenB schedule depends upon the product used. Bexsero (MenB-4C, GSK) is a 2-dose series with doses given at least 1 month apart. Trumenba (MenB-Fhbp, Pfizer) is routinely given as a 2-dose series with doses administered at least 6 months apart. A 3-dose Trumenba schedule is recommended for people who need rapid protection against MenB due to an increased risk of MenB disease and for those who are immunocompromised and may not respond optimally to the 2-dose series. For the 3-dose schedule, dose 2 is given 1-2 months after dose 1 and dose 3 at least 6 months after dose 1.
Penbraya (MenABCWY, Pfizer) contains MenB-Fhbp (Trumenba) and is given as two doses, 6 months apart, when vaccination against all 5 serogroups is needed. For adolescents and adults not at increased risk, if Penbraya is used for dose 1 MenB, Trumenba should be administered for dose 2 MenB. For people age 10 years or older at increased risk of meningococcal disease, Penbraya may be used for additional MenACWY and MenB doses (including booster doses) if both vaccines would be given on the same clinic day and at least 6 months have elapsed since most recent Penbraya dose.
Last reviewed:
March 24, 2024
Meningococcal ACWY
Vaccine Recommendations
We run immunization clinics at the local jail, which has a living arrangement comparable to a college residential hall. In this setting, would you recommend vaccinating incarcerated individuals against meningococcal ACWY disease as is recommended for people living in a college dormitory?
ACIP does not identify incarceration as an indication for meningococcal ACWY vaccination. Providers are always free to use their clinical judgment in situations not addressed by ACIP.
Last reviewed:
November 15, 2024
Pneumococcal
Vaccine Products
What are the different serotypes of S. pneumoniae targeted by different pneumococcal vaccines?
S. pneumoniae bacteria are serotyped based on the polysaccharides in the outer capsule of the bacteria. Serotypes vary in how common they are and in what percentage of pneumococcal disease they cause.
Among the PCV vaccines, PCV13 includes serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F. PCV15 includes all PCV13 serotypes plus 22F and 33F. PCV20 includes all PCV15 serotypes plus 8, 10A, 11A, 12F, and 15B. PPSV23 vaccine does not contain serotype 6A, but contains 19 other serotypes present in PCV20, plus serotypes 2, 9N, 17F, and 20.
PCV21 is designed to target additional serotypes causing a significant proportion of disease in adults that are not prevented by the vaccines approved for children. It does not contain 10 serotypes found in other pneumococcal vaccines approved for children (1, 4, 5, 6B, 9V, 14, 18C, 19F, 23F, 15B, or 2). Instead, it contains an additional 11 serotypes not found in PCV20: 9N, 17F, 20, 15A, 15C, 16F, 23A, 23B, 24F, 31, and 35B. Because of these differences, CDC estimates that PCV20 targets serotypes that cause between 54% and 65% of invasive pneumococcal disease (IPD) in adults, and PCV21 targets serotypes that cause between 77% and 85% of IPD in adults.
PCV13
PCV15
PCV20
PPSV23
PCV21
1
x
x
x
x
3
x
x
x
x
x
4
x
x
x
x
5
x
x
x
x
6A
x
x
x
x
6B
x
x
x
x
7F
x
x
x
x
x
9V
x
x
x
x
14
x
x
x
x
18C
x
x
x
x
19A
x
x
x
x
x
19F
x
x
x
x
23F
x
x
x
x
22F
x
x
x
x
33F
x
x
x
x
8
x
x
x
10A
x
x
x
11A
x
x
x
12F
x
x
x
15B
x
x
2
x
9N
x
x
17F
x
x
20
x
x
15A
x
15C
x
16F
x
23A
x
23B
x
24F
x
31
x
35B
x
Last reviewed:
November 13, 2024
Influenza
Vaccine Recommendations
What influenza vaccines may be used in adults for the 2024-25 season?
All nine 2024-25 influenza vaccines approved for adults are trivalent, containing two influenza A strains and one influenza B strain.
There are five injectable inactivated influenza vaccine (IIV) options approved for use in all adults age 18 years or older. Four egg-based standard dose IIV vaccines (SD-IIVs) and one cell culture-based one (ccIIV) are available, all given as an intramuscular (IM) injection:
One egg-based live attenuated nasal spray vaccine, FluMist (LAIV, AstraZeneca), is an option for healthy, non-pregnant adults through age 49 years: 0.2 mL (given intranasally, 0.1 mL in each nostril).
Three injectable vaccines, all given IM, are ACIP-preferred options for adults age 65 years or older:
Recombinant influenza vaccine, Flublok (RIV, Sanofi): 0.5 mL/dose, licensed for use in adults age 18 or older
Fluzone High-Dose (egg-based HD-IIV, Sanofi): 0.5 mL/dose, licensed for adults age 65 years and older
Fluad (egg-based aIIV with MF59 adjuvant, CSL Seqirus): 0.5 mL/dose, licensed for adults age 65 years and older
Although licensed by FDA for use in adults age 65 years or older, ACIP also recommends off-label use of Fluzone HD or Fluad as acceptable options for influenza vaccination of solid organ transplant recipients age 18 through 64 years who are on immunosuppressive medication regimens, without a preference over other age-appropriate IIVs or RIV.
Last reviewed:
August 11, 2024
Storage & Handling
Vaccine Storage Units
What is NSF/ANSI 456 certification?
A refrigerator or freezer that is NSF-certified for vaccine storage means the units have been tested and certified to meet the NSF/American National Standards Institute (ANSI) 456 standard. The NSF/ANSI 456 standard (or simply “NSF 456” standard) defines the criteria for construction and performance of vaccine refrigerators and freezers used in healthcare settings where vaccines are given. These criteria were developed through a collaboration with NSF, CDC, healthcare providers, public health agencies, equipment manufacturers, and vaccine manufacturers, including experts from Immunize.org.
The NSF 456 certification is a voluntary standard. CDC does not require NSF-certified units for vaccine storage in the Vaccines for Children program or any other federal program. Not all storage units capable of reliably storing vaccines have this certification; however, all storage unit models with this certification have been designed and proven to properly store vaccines under a range of normal clinic conditions. NSF-certified units would be good options for clinic staff to consider when purchasing vaccine storage units.
Last reviewed:
July 26, 2023
Varicella (Chickenpox)
Vaccine Recommendations
Concerning the recommendation for a second dose of varicella vaccine, does CDC recommend that a teen who received only one varicella vaccine when they were preschool age get a second dose now?
Yes. For everyone whose varicella immunity is based on vaccination, 2 doses of varicella vaccine are recommended.
Last reviewed:
May 16, 2023
Hepatitis A
Disease Issues
Can hepatitis A virus (HAV) be transmitted by blood?
Yes. On rare occasions, HAV infection has been transmitted by transfusion of blood or blood products collected from donors during the viremic phase of their infection (i.e., when HAV is in the donor’s blood). Since 2002, tests to detect the presence of hepatitis A virus RNA in donated plasma have drastically reduced the risk of hepatitis A transmission from products derived from blood plasma.
Last reviewed:
June 25, 2023
Scheduling Vaccines
Cholera
Typhoid
Does live oral cholera vaccine need to be administered at an interval from other live oral or injectable vaccines?
In general, no. According to ACIP’s “General Best Practice Guidelines for Immunization”, concerns about spacing between doses of live vaccines not given at the same visit applies only to live injectable or intranasal vaccines. So, live oral cholera vaccine may be administered simultaneously with another vaccine, or at any interval before or after administration of another vaccine. There is one exception: ACIP recommends (based upon expert opinion) that live oral cholera vaccine should be administered at least 8 hours before the first dose of live oral Ty21a typhoid vaccine in order to minimize the risk that the oral cholera vaccine buffer might interfere with the enteric coating of the oral Ty21a vaccine.
Last reviewed:
June 6, 2023
Vaccine Recommendations
What vaccines should I administer to an infant who will be traveling internationally?
Infants who will travel outside the United States should be up to date for all routinely recommended vaccines. One dose of MMR is recommended for infants age 6 through 11 months before international travel. This dose does not count toward the two doses needed to complete the childhood schedule. Infants 6 through 11 months of age traveling to an area at risk for hepatitis A exposure also should receive a dose of hepatitis A vaccine. This dose does not count toward the two doses needed to complete the childhood schedule. Infants younger than age 12 months traveling to a hepatitis A endemic area are not recommended to receive immune globulin for prevention of hepatitis A because immune globulin could interfere with the response to MMR. Varicella vaccine is not recommended before age 12 months, even for travelers. For other vaccine recommendations for travelers, consult the CDC travel website at wwwnc.cdc.gov/travel/.
Last reviewed:
August 22, 2020
Vaccine Safety
How do I report an adverse event to VAERS?
Reports can be submitted online through the VAERS website or by completing and uploading a writable PDF VAERS report form. Both options can be accessed on the VAERS website at vaers.hhs.gov/reportevent.html. If you need further assistance with reporting to VAERS, please email info@VAERS.org or call 1-800-822-7967.
Last reviewed:
August 31, 2022
Rabies
What side effects have been reported with this vaccine?
Most reactions to this vaccine are mild, such as soreness and redness at the injection site. Moderate problems, including hives, pain in the joints, and fever, are possible in a small percentage of patients (6%) given booster doses. Once initiated, rabies prophylaxis should not be interrupted or discontinued because of local or mild systemic adverse reactions to rabies vaccine. Usually, such reactions can be successfully managed with anti-inflammatory and antipyretic agents, such as ibuprofen or acetaminophen.
Last reviewed:
May 14, 2023
Documenting Vaccination
What information does federal law require us to document when we immunize a patient?
It is important to know the federal requirements for documenting the vaccines administered to your patients. The requirements are defined in the National Childhood Vaccine Injury Act enacted in 1986. The law applies to all routinely recommended childhood vaccines, regardless of the age of the patient receiving the vaccines. The only vaccines not included in this law are COVID-19, pneumococcal polysaccharide, zoster, and certain infrequently used vaccines, such as rabies and Japanese encephalitis.
The following information must be documented on the patient’s paper or electronic medical record or on a permanent office log:
The vaccine manufacturer.
The lot number of the vaccine.
The date the vaccine is administered.
The name, office address, and title of the healthcare provider administering the vaccine.
The Vaccine Information Statement (VIS) edition date located in the lower right corner on the back of the VIS. When administering combination vaccines, all applicable VISs should be given and the individual VIS edition dates recorded.
The date the VIS is given to the patient, parent, or guardian.
The federally required information should be both permanent and accessible.
Federal law does not require a parent, patient, or guardian to sign a consent form in order to receive a vaccination; providing them with the appropriate VIS(s) and answering their questions is sufficient under federal law.
Last reviewed:
June 6, 2023
Polio
Is it true that IPV can be given either SC or IM?
Yes.
Last reviewed:
July 23, 2023
Meningococcal ACWY
Vaccine Recommendations
Are there recommendations for meningococcal ACWY vaccination for people who reside in homeless shelters or halfway houses? In addition, can you comment on general vaccination recommendations for people who reside in homeless shelters or halfway houses?
Residence in a homeless shelter or halfway house is considered a high-risk indication only for hepatitis A vaccination because of the increased risk of hepatitis A exposure and serious illness among people experiencing homelessness or living in temporary housing. In all other respects, recommendations for vaccinating adult residents would be the same as those for all adults on the ACIP adult immunization schedule. Residents with medical conditions identified on Table 2 of the schedule should be vaccinated according to that table.
Any residents 18 or younger should be vaccinated according to the catch-up recommendations on the ACIP child/teen immunization schedule. People age 19 through 21 years are not recommended routinely to receive MenACWY. MenACWY may be administered through age 21 years as a catch-up vaccination for those who have not received a dose after their 16th birthday.
Last reviewed:
November 15, 2024
Rotavirus
Scheduling & Administration
If we don’t know which rotavirus vaccine an infant previously received, how should we complete the schedule?
If the product used for a previous dose is unknown, and the infant is at an age when the vaccine can still be given, give a total of 3 doses of rotavirus vaccine. All doses should be administered by age 8 months and 0 days.
