Yes. HepB vaccines have been demonstrated to be safe when administered to infants, children, adolescents, and adults. Since 1982, well over 100 million people, including infants, children, and adults living in the United States have received at least one dose of HepB vaccine; more than a billion doses of HepB vaccine have been given worldwide. Vaccination causes a sore arm occasionally, but serious reactions are very rare.
Last reviewed:
January 17, 2025
Many years of experience with Engerix-B and Recombivax HB vaccines and recent studies of Heplisav-B indicate no apparent risk for adverse events to a developing fetus. Current vaccines contain noninfectious HBsAg and pose no risk to the fetus. If the mother is being vaccinated because of a risk factor for HBV infection (for example, a healthcare worker, a person with a sexually transmitted disease, an injection drug user, a person with multiple sex partners), vaccination should be initiated as soon as the risk factor is identified during the pregnancy. HBV infection during pregnancy might result in severe disease for the mother and chronic infection for the newborn.
Any of the available HepB vaccines (Engerix-B, Heplisav-B, Recombivax HB) or the HepA-HepB combination vaccine, Twinrix, may be used during pregnancy.
Last reviewed:
January 17, 2025
No. Administration of HepB soon after birth has not been associated with an increased rate of elevated temperatures or subsequent evaluations for possible sepsis in the first 21 days of life.
Last reviewed:
January 17, 2025
