Ask the Experts: RSV (Respiratory Syncytial Virus)

Results (68)

The mRNA RSV vaccine (mResvia, Moderna) is supplied as a manufacturer-filled syringe (MFS) that contains a frozen suspension that must be thawed before administration either in the refrigerator or at room temperature. Vaccine should not be refrozen once thawed. Do not shake any mRNA vaccine because shaking can damage the potency of the vaccine by breaking up the small bubbles of fat (lipid) that contain the mRNA.

  • Freezer storage: The frozen vaccine in the plastic MFS can be stored in the freezer between -40°C to -15°C (-40°F to 5°F) until the expiration date printed on its packaging.
  • Refrigerator storage: The thawed plastic MFS may be stored refrigerated between 2°C to 8°C (36°F to 46°F) for up to 30 days before being used. If stored in the refrigerator, place a label on the vaccine indicating when it was placed in the refrigerator and its ‘use by date’, which is 30 days later. Discard an MFS that has been in the refrigerator beyond its 30-day use-by date.
  • Room temperature storage: The thawed plastic MFS may be stored between 8°C to 25°C (46°F to 77°F) for a total of 24 hours after removal from refrigerated conditions. Discard the MFS if not used within this time. Do not return an MFS to the refrigerator after it has been thawed at room temperature.
  • Refer to the mResvia package insert for specific instructions and additional details on storage and thawing: www.fda.gov/media/179005/download.
Last reviewed: August 25, 2024

Nirsevimab (Beyfortus, Sanofi) comes in two single-dose manufacturer-filled syringe (MFS) formulations: 50-mg and 100-mg. Nirsevimab should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). It may be kept at room temperature 68°F to 77°F (20°C to 25°C) for a maximum of 8 hours. After removal from the refrigerator, nirsevimab must be used within 8 hours or discarded. Store nirsevimab in the original carton to protect it from light until time of use. Do not freeze. Do not shake. Do not expose to heat.

Last reviewed: August 25, 2024

No. Seasonal influenza vaccines are reformulated each year; for this reason, all unused seasonal influenza vaccines expire and should be discarded no later than the end of June each season. RSV products (vaccines and preventive antibody) do not change each season and products in your storage unit now may not expire until sometime during or after the next season.

Unless state or territorial public health authorities advise otherwise based upon local conditions, RSV vaccine should not be given during pregnancy after January. Likewise, nirsevimab (Beyfortus, Sanofi) should not be given to infants after March or before October unless specifically instructed by public health authorities.

Vaccination of eligible adults age 60 years or older will have the most benefit if RSV vaccine is administered in late summer or early fall, just before the typical RSV season. However, eligible adults may be vaccinated at any time of year if there is a need to vaccinate at other times of year. Vaccination is expected to provide meaningful protection from serious RSV disease for 2 years or longer. Only one dose of RSV vaccine is recommended: revaccination is not recommended.

Properly store and clearly label unexpired products remaining in your storage unit during periods when they are not in use and train staff on the timing of these products, especially for vaccination during pregnancy and use of nirsevimab. Consider storage and labeling that minimizes the risk of mishandling or administration outside the times when the product is recommended to be used.

Last reviewed: August 25, 2024

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