What is the schedule for MenB?

The MenB schedule depends upon the product used. Bexsero (MenB-4C, GSK) is a 2-dose series with doses given at least 1 month apart. Trumenba (MenB-Fhbp, Pfizer) is routinely given as a 2-dose series with doses administered at least 6 months apart. A 3-dose Trumenba schedule is recommended for people who need rapid protection against MenB due to an increased risk of MenB disease and for those who are immunocompromised and may not respond optimally to the 2-dose series. For the 3-dose schedule, dose 2 is given 1-2 months after dose 1 and dose 3 at least 6 months after dose 1.

Penbraya (MenABCWY, Pfizer) contains MenB-Fhbp (Trumenba) and is given as two doses, 6 months apart, when vaccination against all 5 serogroups is needed. For adolescents and adults not at increased risk, if Penbraya is used for dose 1 MenB, Trumenba should be administered for dose 2 MenB. For people age 10 years or older at increased risk of meningococcal disease, Penbraya may be used for additional MenACWY and MenB doses (including booster doses) if both vaccines would be given on the same clinic day and at least 6 months have elapsed since most recent Penbraya dose.