Issue Number
121
October 22, 1999
UNPROTECTED PEOPLE: Stories of
people who have suffered or died from vaccine-preventable diseases
Story #20:
INFANT DIES OF CONGENITAL RUBELLA SYNDROME
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The following "Unprotected People" story was written
for the Immunization Action Coalition and appeared in the fall/winter 1999-2000 issue of "NEEDLE TIPS and the
Hepatitis B Coalition News":
Infant dies of congenital rubella syndrome
Rubella infection is usually a mild rash illness; however, during the first trimester of pregnancy, it can result in
miscarriage, stillbirth, or an infant with a pattern of birth defects (i.e., congenital rubella syndrome
[CRS]) as described in the following case report.
CASE REPORT: On April 15, 1999, a case of CRS was reported to the Arizona Department of Health Services
in a 1 1/2-month-old Hispanic infant. The infant was born prematurely at 34 weeks gestation. Complications
noted at birth included pulmonary valve stenosis, patent ductus arteriosus, thrombocytopenia, congenital cataracts,
intracranial calcifications, and probable hearing deficits. The 19-year-old foreign-born mother (gravida 1,
para 0) had been living in the United States for two years prior to her pregnancy. She first obtained prenatal care at
four months gestation, at which time she was rubella immune. She reported no rash during the first four
months of pregnancy.
Although the neonate's rubella IgM test was positive shortly after birth, cytomegalovirus was suspected as
the cause of the infant's congenital complications, in part due to the mother's rubella immune status.*
There was a three-week delay in reporting this CRS case to the county health
department. The Maricopa County Department of Public Health immunized household contacts
immediately after receiving this report. The day following vaccination, two of the household contacts, who had
recently moved into the home and participated in the care of the infant, developed rubella-like rash.
The duration between the receipt of vaccine and the rash onset was too short
for the rash to be caused by the vaccine. These contacts, however, could have been infected by the infant
since infants with CRS can shed rubella virus for up to one year and can be the source for rubella outbreaks.
The infant died on June 9, 1999. The cause of death was listed as acute pulmonary hemorrhage as a consequence of
complex congenital heart disease.
This is the fifth case of CRS reported in Arizona since 1994. In all five cases,
the mothers were unimmunized, Hispanic, and foreign born.
- Susan Goodykoontz
Epidemiology Specialist
Arizona Department of Health Services
*Due to the timing of the mother's routine prenatal
serology, it could not be determined when her infection in pregnancy occurred. The infant's defects,
however, were consistent with rubella infection during the first trimester of
pregnancy.
RUBELLA AND CONGENITAL RUBELLA SYNDROME (CRS) ARE VACCINE PREVENTABLE
Since the licensure of the rubella vaccine in 1969 in the United States, the
incidence of rubella and congenital rubella syndrome (CRS) has decreased substantially. Reported rubella and CRS cases have
been at record low levels since the mid 1990s.
Most of the reported rubella cases in the United States since the mid 1990s,
have occurred among young Hispanic adults who were born in countries
either without a national rubella vaccination program or where such programs
were recently implemented. Since 1996, several rubella outbreaks have occurred
in work places such as meat packing plants where a majority of the employees are foreign born.
Almost all countries in the world have measles vaccination programs; however,
in a World Health Organization survey of member countries in 1996, only 78
(36%) of the 214 member countries had national rubella vaccination programs
representing only 20% of the global population. Because both are rash illnesses, many people confuse rubella
and measles. In several of the recent outbreaks, many people thought they had been vaccinated for
rubella, but instead they had been vaccinated for measles.
- Susan E. Reef, MD
Leader, Mumps Rubella Team
National Immunization Program, CDC
ACTION YOU CAN TAKE TO PREVENT RUBELLA AND THE
SUBSEQUENT TRAGIC CONSEQUENCES OF CRS
- VACCINATE PERSONS WHO DO NOT HAVE DOCUMENTED PROOF OF
IMMUNITY TO RUBELLA.
In the United States, children should receive the first dose of MMR vaccine at age 12-15 months and the second dose at 4-6 years of age.
Persons who are born after 1957 and who do not have a medical contraindication should receive at least one dose of MMR vaccine unless
they have documentation of vaccination with at least one dose of measles-, rubella-, and mumps-containing vaccine.
- MAKE SURE YOUR FOREIGN-BORN PATIENTS ARE VACCINATED.
Rubella and CRS are at record low levels in the United States, primarily due to the success of the rubella vaccination program. However, rubella
vaccination programs have only recently been introduced in many developing countries and many foreign-born persons may not be
immune to rubella.
- THINK RUBELLA WHEN YOU SEE SUSPICIOUS RASHES.
Even though rubella is at record low levels, it still is introduced and it spreads in the United States. If someone presents with a rash illness that
may be consistent with rubella or measles, rubella needs to be ruled out.
Obtaining a rubella-specific IgM blood test is critical.
- THINK CRS WHEN YOU SEE ANY CONGENITAL MALFORMATION
CONSISTENT WITH CRS.
CRS is rare in the United States, however, it does occur. In an infant born with ANY congenital malformation consistent with CRS, do not
assume that a positive rubella titer drawn during pregnancy rules out
CRS. If you suspect CRS, obtain a rubella-specific IgM blood test.
- REPORT ALL CASES OF RUBELLA AND CRS TO YOUR LOCAL
OR STATE HEALTH DEPARTMENT.
Once a case of rubella or CRS has been identified, the health department must be contacted immediately. All cases should be
investigated and control measures implemented.
- SE Reef, MD
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DON'T MISS THE DIAGNOSIS OF CONGENITAL RUBELLA SYNDROME!
Classical findings include congenital heart defects,
cataracts, and hearing loss.
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